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29
Jan
Collagen: Structure, Functions, and Biomedical Applications
The "Scaffold of Life" — Exploring the most abundant protein in the human body.
Collagen is the most abundant structural protein in the human body, accounting for approximately 30% of total body protein. It is essential for the integrity of skin, bone, tendons, and blood vessels.
I. Molecular Structural Characteristics
Collagen's hallmark is its triple-helix conformation. This unique architecture confers exceptional mechanical strength, allowing tissues to withstand significant stress.
Hierarchical Assembly
1. Primary Structure: Repeating sequence of Gly-Pro-X. Glycine (1/3 of total) allows tight packing of the helix.
2. Triple-Helix: Three left-handed alpha-chains intertwine into a right-handed superhelix, stabilized by interchain hydrogen bonds.
3. Superhelical Assembly: The "rope-like" twist provides resistance to environmental stress and enzymatic degradation.
4. Fibril & Fiber: Procollagen aligns in a quarter-staggered pattern with covalent cross-links to form high-tensile fibers.
II. Core Functions & Biomedical Applications
✨ Skin Elasticity & Anti-Aging
Acts as the skin's "scaffold." Supplementation stimulates fibroblast activity and repairs elastic fibers to reduce fine lines.
🦴 Bone & Joint Health
Constitutes 90% of bone matrix. Collagen peptides promote chondrocyte activity to support cartilage repair and bone density.
🩹 Wound Healing
Provides a critical matrix for cell migration and angiogenesis. Collagen-based dressings accelerate surgical wound closure.
🩸 Vascular Integrity
Maintains blood vessel wall compliance. Helps inhibit pathological cross-linking to support cardiovascular health.
Biofargo team
