Biochemical reagents

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APC-H-2Db/LCMV gp33 (C9M) (KAVYNFATM) MHC Tetramer

Description  This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of LCMV-derived peptide of KAVYNFATM sequence covering 33-41 and H-2Db molecule. The pMHC tetramer recognizes mouse...


Description PLX-5622 is a highly selective brain-penetrant CSF1R inhibitor (IC50=0.016 µM; Ki=5.9 nM) allowing for extended and specific microglial elimination, preceding and during pathology development. Notice: PLX-5622 also works well...

MLN-4924 (Pevonedistat)

Description MLN-4924 (Pevonedistat) is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with potential antineoplastic activity. NAE inhibitor MLN-4924 binds to and inhibits NAE, which may result in the...


Description BDTX-1535 is an orally bioavailable, brain-penetrating, mutation-selective, EGFR inhibitor with potential antitumor activity.BDTX-1535 is a fourth-generation EGFR inhibitor that overcomes resistance to Osimertinib, the standard of care for EGFR-mutant...


Description BI-2865 is a pan-KRAS inhibitor disables oncogenic signalling and tumour growth. BI-2865 blocks nucleotide exchange to prevent the activation of wild-type KRAS and a broad range of KRAS mutants,...

BMS-906024, Purity: 98.10%

Description: BMS-906024 is an orally active and selective γ-secretase (gamma secretase) inhibitor. BMS-906024 is a potent pan-Notch receptors inhibitor with IC50s of 1.6 nM, 0.7 nM, 3.4 nM, and 2.9...