Bcakground Interleukin-28A (IL-28A) , IL-28B, and IL-29, also named interferon-lambda 2 (IFN-lambda 2), IFN-lambda 3, and IFN-lambda 1, respectively, are class II cytokine receptor ligands that are distantly related to...
Bcakground Granulocyte Macrophage Growth Factor(GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. In response to cytokine or inflammatory stimuli, GM-CSF is...
The dickkopf family of proteins are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling....
CSF1 is a four-alpha -helical-bundle cytokine, the primary regulator of macrophage survival, proliferation and differentiation. It is also essential for the survival and proliferation of osteoclast progenitors, and primes and...
Bcakground Dickkopf related protein 1 (Dkk-1) is the founding member of the Dickkopf family of proteins that includes Dkk-1, -2, -3, -4, and a related protein, Soggy (1, 2). Dkk...
Bcakground Insulin-like growth factor binding protein-3 (IGFBP-3)is one of six members of the insulinlike growth factor (IGF) binding protein superfamily which function to modulate the biological activity of IGF (1)....
Bcakground Interferon-alpha 2 (IFN alpha -2) is one of 14 subtypes within the IFN-alpha class of Type I Interferons (1). The members of the IFN-alpha class, also known as alpha...
Bcakground Vascular Endothelial Growth Factor (VEGF) is a potent growth factor that promotes both angiogenesis and vascular permeability (1–3). It acts on endothelial cells by signaling primarily through two VEGF...