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Disclaimer: For laboratory research use only.
$50.00
Sku: C-1521-5
Categories:
Biochemical reagents, Chemical, Hot-sale Products
Description
PLX-5622 is a highly selective brain-penetrant CSF1R inhibitor (IC50=0.016 µM; Ki=5.9 nM) allowing for extended and specific microglial elimination, preceding and during pathology development. Notice: PLX-5622 also works well by intraperitoneal injection (IP), See: Cell Rep. 2022 Aug 16;40(7):111209. Microglia contribute to the postnatal development of cortical somatostatin-positive inhibitory cells and to whisker-evoked cortical activity. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396528/ Method details Microglia depletion in postnatal pups PLX5622 stock was dissolved in DMSO at a final concentration of 100mg/mL. Pups were injected intraperitoneally every day, from P2 until the day before brain collection, with 0.5μL/g of PLX5622 stock solution diluted in at least an equal volume of DMSO (PLX5622 final concentration is 50μg/g of mouse). PLX-5622 was purchased from Chemgood.
Technical Data
Product Name: PLX-5622
Chemical Formula: C21H19F2N5O
Molecular Weight: 395.41
CAS#: 1303420-67-8
Appearance: Solid powder
Purity: > 99% by HPLC
Solubility: Soluble in DMSO
Storage: Room temperature for months, or -20ºC for 3 years
Targets: CSF-1R
Synonym: PLX-5622; PLX5622; PLX 5622
Chemical Name/IUPAC:3-Pyridinemethanamine, 5-fluoro-N-[6-fluoro-5-][(5-methyl-1H-pyrrolo][2,3-b]pyridin-3-yl)methyl
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