Bcakground Leptin is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in the...
Trem-like transcript 2 protein (TLT-2; also TREML2) is a 33 kDa (unglycosylated) type I transmembrane cell surface receptor and member of the Trem family of receptor proteins. TLT-2 plays a...
Bcakground Thrombopoietin (Tpo) is a key regulator of megakaryocytopoiesis and thrombopoiesis. It is principally produced in the liver and is bound and internalized by the receptor TpoR/c-Mpl. Defects in the...
Bcakground Interleukin-7 (IL-7) , is a 25 kDa cytokine of the hemopoietin family that plays important roles in lymphocyte differentiation, proliferation, and survival (1-4). Human IL-7 cDNA encodes 177 amino...
Bcakground Interleukin 23 is a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of...
Bcakground Stem cell factor (SCF) , also known as c-kit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28 - 40 kDa type...
Bcakground Interleukin-2 (IL-2) is an O-glycosylated four α-helix bundle cytokine that has potent stimulatory activity for antigen-activated T cells. It is expressed by CD4⁺ and CD8⁺ T cells, γδ T...
Bcakground Interleukin-15 (IL-15) is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. (1, 2). Mature human IL-15...