L-Methionine

Description

Molecular Formula: C5H11NO2S 

Molecular Weight: 149.2 

CAS Number: 63-68-3 

pKA: 2.28, 9.21 

Melting Point: 280 - 282 °C 

Rotation: +23.40 (50 mg/ml, 6 M HCl, 20 °C)

Methionine is one of the common sulfur-containing amino acids. The biosynthesis of methionine 
initially occurs by the condensation of homoserine and succinyl-CoA via the action of homoserine acyltransferase. Subsequently, cystathionine g-synthase displaces the succinate group with cysteine to give cystathionine. Cystathionine a-lyase then hydrolyzes cystathionine to produce homocysteine. Transfer of a methyl group from N5-methyltetrahydrofolate to the homocysteine forms methionine.

Methionine is a common methyl-group donor to various substrates, such as creatine, epinephrine, ergosterol, and choline. Methionine is a relatively hydrophobic amino acid residue, and as such is frequently buried in protein three-dimensional structure, making modification of methionine residues difficult.

A review of the oxidation of methionine as it relates to oxidation of b-amyloid peptides has been 
published.

Precautions and Disclaimer 

For Laboratory Use Only. Not for drug, household or other uses.

Preparation Instructions

This product is soluble in 1 M HCl (50 mg/ml), yielding a clear, colorless solution. This product is 
also soluble in water (50 mg/ml), with heat as needed.

Storage/Stability

Stock solutions are stable for approximately five years at 2 - 8 °C

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Disclaimer: For laboratory research use only.