Description M-CSF is a disulfide-linked homodimeric glycoprotein and core member of the colony-stimulating factor family. By specifically binding the c-Fms receptor (CSF-1R/CD115), it induces receptor dimerization and internalization and activates...

Trem-like transcript 2 protein (TLT-2; also TREML2) is a 33 kDa (unglycosylated) type I transmembrane cell surface receptor and member of the Trem family of receptor proteins. TLT-2 plays a...

Bcakground Stem cell factor (SCF) , also known as c-kit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28 - 40 kDa type...

Bcakground Interleukin-2 (IL-2) is an O-glycosylated four α-helix bundle cytokine that has potent stimulatory activity for antigen-activated T cells. It is expressed by CD4⁺ and CD8⁺ T cells, γδ T...

Bcakground Interleukin-27 (IL-27) is a heterodimeric group 2 receptor ligand molecule that belongs to the IL-6/IL-12 family of long type I cytokines (1). It is composed of EBI3 (EBV-induced gene...

Bcakground Interleukin-28A (IL-28A) , IL-28B, and IL-29, also named interferon-lambda 2 (IFN-lambda 2), IFN-lambda 3, and IFN-lambda 1, respectively, are class II cytokine receptor ligands that are distantly related to...

Bcakground Placenta growth factor (PlGF) is a member of the PDGF/VEGF family of growth factors that share a conserved pattern of eight cysteines (1, 2). Alternative splicing results in at...

Bcakground Insulin-like growth factor binding protein-3 (IGFBP-3)is one of six members of the insulinlike growth factor (IGF) binding protein superfamily which function to modulate the biological activity of IGF (1)....