Most cell types express three sizes of receptors for TGF-beta. These are designated type I (53 kDa), type II (70-85 kDa), and type III (250-350 kDa). The type II receptor...
Bcakground Noggin is a secreted homodimeric glycoprotein that is an antagonist of bone morphogenetic proteins (BMPs) (1, 2). Secreted Noggin probably remains close to the cell surface due to its...
GPC (glypicans) are a family of heparan sulfate proteoglycans that are attached to the cell surface by a glycosylphosphatidylinositol anchor. Mutations in GPC3 cause a rare disorder in humans, Simpson-Golabi-Behmel...
Bcakground Oncostatin M (OSM)is a glycoprotein belonging to the interleukin-6 family of cytokines that has functions mainly in cell growth. Oncostatin M (OSM) is considered as a pleiotropic cytokine that...
VEGF is a potent growth factor that promotes both angiogenesis and vascular permeability. It acts on endothelial cells by signaling primarily through two VEGF receptors, VEGF R1 (also called Flt-1)...
Bcakground Epidermal growth factor (EGF) is a small, potent growth factor capable of inducing cell proliferation, differentiation, and survival. EGF is the founding member of the EGF family that also...
Bcakground Oncostatin M (OSM)is a member of a cytokine subfamily that includes IL-6, IL-11, LIF, CNTF, and cardiotrophin-1. These cytokines have overlapping biological functions and shared receptor components. Mouse OSM...
Bcakground Epidermal growth factor (EGF) is a small, potent growth factor capable of inducing cell proliferation, differentiation, and survival. EGF is the founding member of the EGF family that also...