Human TROP-2, also called tumor associated calcium signal transducer 2 (TACSTD2), GA733-1, gp50 and T16, is a type I cell surface glycoprotein that is highly expressed on human carcinomas. The...
Bcakground Granulocyte Colony Stimulating Factor(G-CSF)is a pleiotropic cytokine best known for its specific effects on the proliferation, differentiation, and activation of hematopoietic cells of the neutrophilic granulocyte lineage. It is...
Bcakground R-Spondin 1 (RSPO1), also known as cysteine-rich and single thrombospondin domain containing protein 3 (Cristin 3), is a 27 kDa secreted protein that shares ~40% amino acid (aa) identity...
Bcakground Interleukin-28B (also named interferon-lambda 3, IFN-lambda 3) , IL-28A (IFN-lambda 2) and IL-29 (IFN-lambda 1) are type III interferons that are class II cytokine receptor ligands (1-4). They are...
Bcakground Interleukin-28A (IL-28A) , IL-28B, and IL-29, also named interferon-lambda 2 (IFN-lambda 2), IFN-lambda 3, and IFN-lambda 1, respectively, are class II cytokine receptor ligands that are distantly related to...
Bcakground Granulocyte Macrophage Growth Factor(GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. In response to cytokine or inflammatory stimuli, GM-CSF is...
The dickkopf family of proteins are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling....
CSF1 is a four-alpha -helical-bundle cytokine, the primary regulator of macrophage survival, proliferation and differentiation. It is also essential for the survival and proliferation of osteoclast progenitors, and primes and...