Kanamycin sulfate

Description

Kanamycin sulfate, identified by the CAS number 70560-51-9, is an aminoglycoside antibiotic derived from the bacterium Micromonospora purpurea. It is primarily used to treat infections caused by certain bacteria, particularly those resistant to other antibiotics. The substance exhibits a broad spectrum of antibacterial activity, particularly against Gram-negative bacteria, and is often employed in clinical settings for serious infections. Kanamycin functions by inhibiting bacterial protein synthesis, leading to cell death. The sulfate form enhances its solubility in water, making it suitable for parenteral administration. In terms of physical characteristics, kanamycin sulfate is typically a white to off-white powder, hygroscopic in nature, and stable under proper storage conditions. It is important to note that kanamycin can have nephrotoxic and ototoxic side effects, necessitating careful monitoring during treatment. Additionally, it is crucial to consider potential allergic reactions and interactions with other medications when prescribing kanamycin sulfate.

Specifications

Application

Kanamycin sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus. It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium.†† Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100 μg/mL.

Biochem/physiol Actions

Mode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding.

Mode of Resistance: Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes.

Antimicrobial Spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.

Documents

COA

SDS

Disclaimer: For laboratory research use only.