Description PLX-5622 is a highly selective brain-penetrant CSF1R inhibitor (IC50=0.016 µM; Ki=5.9 nM) allowing for extended and specific microglial elimination, preceding and during pathology development. Key Features CSF1R Inhibition: PLX-5622...

Description Potassium periodate is widely used as an oxidizing agent.[1] It produces singlet oxygen (1O2) in alkaline medium via a non-photochemical pathway. This singlet oxygen can selectively oxidizes aqueous organic...

Description Propylene glycol, a low-molecular-weight aliphatic alcohol, holds significance as a key solvent in biological and pharmaceutical formulation research. Its outstanding miscibility with water and diverse organic compounds, coupled with...

Description Pyrogallol is sensitive to air and light and may become grayish or darker after exposure. Laboratories handling this material therefore need a clearly defined assay specification, controlled impurity limits,...

Description Resiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of transient receptor potential vanilloid 1 (TRPV1) receptor agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory...

Description RMC-0331 is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction. Specification Catalog...

Description RMC-6236, also known by its chemical synonym daraxonrasib, is a high-purity, first-in-class pan-RAS inhibitor designed exclusively as a research compound. Registered under CAS 2765081-21-6, this potent molecule targets the...

Description RMC-7977 is a reversible, tri-complex RAS inhibitor with broad spectrum activity for both mutant and wild-type (WT) KRAS, NRAS, and HRAS variants (a RASMULTI(ON) inhibitor). Preclinically, RMC-7977 demonstrated potent...