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Full name | TGFB1 mouse monoclnal antibody |
Alternative names | 50 μl/100 μl |
Reactivity | mouse monoclonal |
Applications | WB, IHC |
Host | Mouse |
Clone type | mouse monoclonal |
Target Background | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. |
Swissprot No | P01137 |
Gene Accession | |
WB Predicted band size | |
WB Positive control | P113920-WB-1-P |
WB Recommended dilution | 44 kDa |
IHC predicted cell location | Predicted cell location: Secreted |
IHC positive control | Positive control: Human cervical cancer and Human thyroid cancer |
IHC Recommed dilution | Recommended dilution: 100-500 |
Ascitic fluid with 0.05% sodium azide and 40% glycerol
P113920-WB-1-P
Immunohistochemical analysis of paraffin-embedded Human cervical cancer and Human thyroid cancer tissue using P113920(TGFB1 Antibody) at dilution 1/150
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