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Specification
| Full name | VDAC1 rabbit polyclonal antibody |
| Alternative names | 50 μl/100 μl |
| Reactivity | rabbit polyclonal |
| Applications | WB, IHC |
| Host | Rabbit |
| Clone type | rabbit polyclonal |
| Target Background | Voltage-dependent anion channel (VDAC), ubiquitously expressed and located in the outer mitochondrial membrane, is generally thought to be the primary means by which metabolites diffuse in and out of the mitochondria. In addition, this channel plays a role in apoptotic signaling. The change in mitochondrial permeability characteristic of apoptosis is mediated by Bcl-2 family proteins, which bind to VDAC, altering the channel kinetics. Homodimerization of VDAC may be a mechanism for changing mitochondrial permeability and supporting release of cytochrome c. In mammalian cells, there are three VDAC isoforms, VDAC1, which is the most widely expressed isoform, as well as VDAC2 and VDAC3. |
| Swissprot No | P21796 |
| Gene Accession | BC008482 |
| WB Predicted band size | Immunohistochemical analysis of paraffin-embedded Human tonsil tissue or VDAC1 antigen-treated (Neutralization experiment) using P101373(VDAC1 Antibody) at dilution 1/150 |
| WB Positive control | P101373-WB-1-P |
| WB Recommended dilution | 31 kDa |
| IHC predicted cell location | Predicted cell location: Cytoplasm |
| IHC positive control | Positive control: Human prostate cancer |
| IHC Recommed dilution | Recommended dilution: 150-300 |
Storage
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
WB PIC Description
P101373-WB-1-P
IHC PIC Description
Immunohistochemical analysis of paraffin-embedded Human prostate cancer tissue or VDAC1 antigen-treated (Neutralization experiment) using P101373(VDAC1 Antibody) at dilution 1/150
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