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Specification
| Full name | TOP2A rabbit monoclonal antibody |
| Alternative names | 50 μl/100 μl |
| Reactivity | rabbit monoclonal |
| Applications | WB, IHC |
| Host | Rabbit |
| Clone type | rabbit monoclonal |
| Target Background | This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010] |
| Swissprot No | P11388 |
| Gene Accession | 7153 |
| WB Predicted band size | |
| WB Positive control | P291559-WB-1-P |
| WB Recommended dilution | 174 kDa |
| IHC predicted cell location | Predicted cell location: Nucleus |
| IHC positive control | Positive control: Human colon cancer |
| IHC Recommed dilution | Recommended dilution: 50-100 |
Storage
-20°C, Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Avoid repeated freeze-thaw cycles.
WB PIC Description
P291559-WB-1-P
IHC PIC Description
Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using P291559(TOP2A Antibody) at dilution 1/50
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
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