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Full name | TNNI3 rabbit polyclonal antibody |
Alternative names | 50 μl/100 μl |
Reactivity | rabbit polyclonal |
Applications | WB, IHC |
Host | Rabbit |
Clone type | rabbit polyclonal |
Target Background | Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19. |
Swissprot No | P19429 |
Gene Accession | BC096165 |
WB Predicted band size | |
WB Positive control | P104588-WB-1-P |
WB Recommended dilution | 24 kDa |
IHC predicted cell location | Predicted cell location: Cytoplasm |
IHC positive control | Positive control: Human colorectal cancer |
IHC Recommed dilution | Recommended dilution: 50-100 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
P104588-WB-1-P
Immunohistochemical analysis of paraffin-embedded Human colorectal cancer tissue or TNNI3 antigen-treated (Neutralization experiment) using P104588(TNNI3 Antibody) at dilution 1/50
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