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Specification
| Full name | TNFSF11 rabbit polyclonal antibody |
| Alternative names | 50 μl/100 μl |
| Reactivity | rabbit polyclonal |
| Applications | WB, IHC |
| Host | Rabbit |
| Clone type | rabbit polyclonal |
| Target Background | This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. |
| Swissprot No | O14788 |
| Gene Accession | NP_003692 |
| WB Predicted band size | |
| WB Positive control | P104173-WB-1-P |
| WB Recommended dilution | 36 kDa |
| IHC predicted cell location | Predicted cell location: Cytoplasm |
| IHC positive control | Positive control: Human liver cancer |
| IHC Recommed dilution | Recommended dilution: 30-150 |
Storage
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
WB PIC Description
P104173-WB-1-P
IHC PIC Description
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue or TNFSF11 antigen-treated (Neutralization experiment) using P104173(TNFSF11 Antibody) at dilution 1/25
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Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
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