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Sku: P101160-50 μl

Specification

Full name SMC1A rabbit polyclonal antibody
Alternative names 50 μl/100 μl
Reactivity rabbit polyclonal
Applications WB, IHC
Host Rabbit
Clone type rabbit polyclonal
Target Background Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Swissprot No Q14683
Gene Accession BC112127
WB Predicted band size Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue or SMC1A antigen-treated (Neutralization experiment) using P101160(SMC1A Antibody) at dilution 1/30
WB Positive control P101160-WB-1-P
WB Recommended dilution 143 kDa
IHC predicted cell location Predicted cell location: Nucleus
IHC positive control Positive control: Human esophagus cancer
IHC Recommed dilution Recommended dilution: 25-100

Storage

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

WB PIC Description

P101160-WB-1-P

IHC PIC Description

Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue or SMC1A antigen-treated (Neutralization experiment) using P101160(SMC1A Antibody) at dilution 1/30

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