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Full name | RRP8 rabbit polyclonal antibody |
Alternative names | 50 μl/100 μl |
Reactivity | rabbit polyclonal |
Applications | WB, IHC |
Host | Rabbit |
Clone type | rabbit polyclonal |
Target Background | Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. |
Swissprot No | O43159 |
Gene Accession | BC001071 |
WB Predicted band size | Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue or RRP8 antigen-treated (Neutralization experiment) using P112896(RRP8 Antibody) at dilution 1/80 |
WB Positive control | P112896-WB-1-P |
WB Recommended dilution | 51 kDa |
IHC predicted cell location | Predicted cell location: Cytoplasm and Nucleus |
IHC positive control | Positive control: Human esophagus cancer |
IHC Recommed dilution | Recommended dilution: 50-300 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
P112896-WB-1-P
Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue or RRP8 antigen-treated (Neutralization experiment) using P112896(RRP8 Antibody) at dilution 1/80
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