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Specification
| Full name | RRP8 rabbit polyclonal antibody |
| Alternative names | 50 μl/100 μl |
| Reactivity | rabbit polyclonal |
| Applications | WB, IHC |
| Host | Rabbit |
| Clone type | rabbit polyclonal |
| Target Background | Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. |
| Swissprot No | O43159 |
| Gene Accession | BC001071 |
| WB Predicted band size | Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue or RRP8 antigen-treated (Neutralization experiment) using P112896(RRP8 Antibody) at dilution 1/80 |
| WB Positive control | P112896-WB-1-P |
| WB Recommended dilution | 51 kDa |
| IHC predicted cell location | Predicted cell location: Cytoplasm and Nucleus |
| IHC positive control | Positive control: Human esophagus cancer |
| IHC Recommed dilution | Recommended dilution: 50-300 |
Storage
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
WB PIC Description
P112896-WB-1-P
IHC PIC Description
Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue or RRP8 antigen-treated (Neutralization experiment) using P112896(RRP8 Antibody) at dilution 1/80
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We also provide express shippping for time-sensitive deliveries.
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