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Sku: P112896-50 μl
Categories: Primary Antibodies

Specification

Full name RRP8 rabbit polyclonal antibody
Alternative names 50 μl/100 μl
Reactivity rabbit polyclonal
Applications WB, IHC
Host Rabbit
Clone type rabbit polyclonal
Target Background Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Swissprot No O43159
Gene Accession BC001071
WB Predicted band size Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue or RRP8 antigen-treated (Neutralization experiment) using P112896(RRP8 Antibody) at dilution 1/80
WB Positive control P112896-WB-1-P
WB Recommended dilution 51 kDa
IHC predicted cell location Predicted cell location: Cytoplasm and Nucleus
IHC positive control Positive control: Human esophagus cancer
IHC Recommed dilution Recommended dilution: 50-300

Storage

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

WB PIC Description

P112896-WB-1-P

IHC PIC Description

Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue or RRP8 antigen-treated (Neutralization experiment) using P112896(RRP8 Antibody) at dilution 1/80

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