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Disclaimer: For laboratory research use only.
$400.00
Sku: RMC7977-5
Categories:
Chemical, Hot-sale Products
Description
RMC-7977 is a reversible, tri-complex RAS inhibitor with broad spectrum activity for both mutant and wild-type (WT) KRAS, NRAS, and HRAS variants (a RASMULTI(ON) inhibitor). Preclinically, RMC-7977 demonstrated potent activity against RAS-addicted tumors carrying various RAS genotypes, particularly cancer models with KRAS codon 12 mutations (KRAS G12X ). RMC-7977 led to tumor regressions and was well tolerated in diverse RAS-addicted preclinical cancer models. Additionally, RMC-7977 inhibited the growth of KRAS G12C cancer models that are resistant to KRAS G12C inhibitors due to restoration of RAS pathway signaling.
Specification
| Catalog NO. | CT-RMC7977 |
| Synonym | RMC7977 |
| CAS NO | 2765082-12-8 |
| Mol. Formula | C47H60O6N8S |
| MW | 865.1 |
Document
Disclaimer: For laboratory research use only.
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