Resiniferatoxin

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Description

Resiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of transient receptor potential vanilloid 1 (TRPV1) receptor agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period.

In Vitro

  • Resiniferatoxin causes extremely prolonged channel opening and calcium influx, which results in cytotoxicity to the TRPV1-positive pain fibers or cell bodies[1].

    Biofargo has not independently confirmed the accuracy of these methods. They are for reference only.

  • Resiniferatoxin Related Antibodies

    TRPM8 Antibody

    TRPM7 Antibody 

    TrpC1 Antibody

In Vivo

Resiniferatoxin (2 μg/10 μl; injected intrathecally into the T2/T3 interspace; four weeks after coronary artery occlusion to induce heart failure in rats) significantly and selectively abolishes the afferent markers expression (TRPV1 and calcitonin gene-related peptide) in dorsal horn and reduced overactivated CSNA. Resiniferatoxin significantly reverses the prolongation of action potential duration (APD) and APD alternan, reduces the inducibilities of ventricular arrhythmias

Biofargo has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number Sponsor Condition Start Date Phase
NCT02522611 National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) Intractable Pain|Palliative Care October 1, 2023 Phase 1|Phase 2
NCT05695339 National Institutes of Health Clinical Center (CC) Morton´s Neuroma August 28, 2023 Phase 1
NCT04572776 Sorrento Therapeutics, Inc. Pain, Intractable|Pain Cancer December 2020 Phase 3
NCT03542838 Sorrento Therapeutics, Inc. Osteoarthritis, Knee|Pain, Knee July 12, 2018 Phase 1
NCT05067257 Sorrento Therapeutics, Inc. Pain, Intractable|Pain Cancer|Pain September 2023 Phase 2
NCT04386980 Sorrento Therapeutics, Inc. Osteoarthritis, Knee|Osteo Arthritis Knee|Knee Pain Chronic April 2021 Phase 3
NCT04885972 Sorrento Therapeutics, Inc. Osteoarthritis, Knee|Knee Osteoarthritis|Knee Pain Chronic November 15, 2021 Phase 2
NCT04044742 Sorrento Therapeutics, Inc. Osteoarthritis, Knee|Knee Pain Chronic December 2020 Phase 3
NCT00804154 National Institute of Dental and Craniofacial Research (NIDCR)|National Institute of Neurological Disorders and Stroke (NINDS)|Sorrento Therapeutics, Inc.|National Institutes of Health Clinical Center (CC) Intractable Pain|Palliative Care December 2020 Phase 1
NCT03226574 Sorrento Therapeutics, Inc. Intractable Cancer Pain September 1, 2017 Phase 1

 

Specifications

CAS No. 57444-62-9
Formula C37H40O9
Molecular Weight 628.71
Appearance Solid
SMILES C[C@H]1[C@][C@][C@]4([C@@]3([H][H])[C@]6([H])[C@][C@](O2)(O6)CC7=CC=CC=C7)C(C)=C
Initial Source Plants > Euphorbiaceae > Euphorbia resinifera O. Berg
Shipping Room temperature in continental US; may vary elsewhere.
Storage -20°C, protect from light
In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

 

Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration
/ Solvent
/ Mass		 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5906 mL 7.9528 mL 15.9056 mL 39.7640 mL
5 mM 0.3181 mL 1.5906 mL 3.1811 mL 7.9528 mL
10 mM 0.1591 mL 0.7953 mL 1.5906 mL 3.9764 mL
15 mM 0.1060 mL 0.5302 mL 1.0604 mL 2.6509 mL
20 mM 0.0795 mL 0.3976 mL 0.7953 mL 1.9882 mL
25 mM 0.0636 mL 0.3181 mL 0.6362 mL 1.5906 mL
30 mM 0.0530 mL 0.2651 mL 0.5302 mL 1.3255 mL
40 mM 0.0398 mL 0.1988 mL 0.3976 mL 0.9941 mL
50 mM 0.0318 mL 0.1591 mL 0.3181 mL 0.7953 mL
60 mM 0.0265 mL 0.1325 mL 0.2651 mL 0.6627 mL

 

Documents

Data Sheet

SDS

COA

Handling Instruction

Publications

Cell Rep. 2024 Oct 15;43(10):114859. 

References

[1]. Brown DC. Resiniferatoxin: The Evolution of the "Molecular Scalpel" for Chronic Pain Relief. Pharmaceuticals (Basel). 2016;9(3):47. Published 2016 Aug 11. 

[2]. Wu Y, et al. Resiniferatoxin reduces ventricular arrhythmias in heart failure via selectively blunting cardiac sympathetic afferent projection into spinal cord in rats. Eur J Pharmacol. 2020;867:172836.  

For research use only. We do not sell to patients.

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