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$238.00
Sku: Y03801-50ug
Availability:
AVAILABLE
In stock & estimated to ship in 3-7 days by March 20, 2026
Description
SCF (Stem Cell Factor), also known as KIT ligand or mast cell growth factor, is a glycoprotein that exists in both soluble and membrane-bound forms. It functions by binding to the c-KIT receptor on the cell surface and activating downstream signaling pathways. When used in combination with other cytokines—such as IL-3, IL-6, and FLT3 ligand—SCF promotes the expansion of hematopoietic stem and progenitor cells in vitro. It acts synergistically with EPO to support erythroid progenitor differentiation and with TPO to enhance megakaryopoiesis. In organoid culture systems, SCF helps maintain the activity of intestinal stem cells, mammary stem cells, and other tissue-specific stem cells. The core functions of SCF in cell culture include sustaining stem cell activity, promoting proliferation, and inhibiting apoptosis. It is particularly indispensable in in vitro studies of the hematopoietic system and specific lineage development. Its applications span foundational research, regenerative medicine, and drug development.
Specifications
| Product Details | |
|---|---|
| Cat. No. | Y03801 |
| Purity | ≥95%, by SDS-PAGE (under reducing (R) & Non-reducing conditions, visualized by Coomassie staining). |
| Endotoxin | ≤10 EU/mg by the LAL method. |
| Bioactivity | Measured in a cell proliferation assay using TF-1 cells. The ED50 for this effect is 5-8 ng/mL. |
| Accession | P21583 |
| Alternative Names | Kit Ligand; Mast Cell Growth Factor; MG/VAIL F; Stem Cell Factor; SCF; c-Kit ligand; KITLG; MG/VAIL F; SCF |
| Species | Human |
| Expression System | CHO |
| Mol. Weight | 18.5 kDa |
| Expression Region | Glu 26-Ala 190 |
| Tag Info | Tag free |
| Formulation | Lyophilized |
| Buffer | PBS, 5% Mannitol and 0.01% Tween 80, pH7.4. |
| Size | 10μg/50μg/1mg |
| Lead Time | Products are in stock, but custom products may require further consultation. |
| Reconstitution | It is recommended to redissolve in sterile deionized water. |
| Shipping | The product is shipped with blue ice. |
| Storage & Stability | 36 months at -20°C to -80°C in lyophilized state;6 months at -20°C to -80°C under sterile conditions after reconstitution;7-10 days at 2°C to 8°C under sterile conditions after reconstitution;Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
Features
- ✔ High Purity: This product undergoes stringent purification processes, achieving a purity level of over 95%,ensuring the reliability and reproducibility of experimental results.
- ✔ High Biological Activity: Verified through multiple activity assays, this product effectively induces the expectedbiological responses in target cells.
- ✔ Batch Consistency: Manufactured under strict production and quality control protocols to ensure highconsistency between batches.
- ✔ Animal-Free: Produced without the use of animal-derived components, meeting animal-free requirements.
Applications
Hematology
Key hematopoietic growth factor, supports HSC proliferation and survival.
Stem Cell Research
Essential for hematopoietic stem cell maintenance and expansion in vitro.
Cell Biology
Regulates stem/progenitor cell survival, proliferation, and adhesion via c-Kit signaling.
Data Figures
Figure 1: Recombinant Human SCF (Cat. No. Y03801) SDS-PAGE under reducing (R) & Non-reducing conditions. The gel was stained with Y03801 SDS-PAGE.
Figure 2: Recombinant Human SCF (Cat. No. Y03801) stimulates proliferation of TF-1 cells. The ED50 for this effect is 5-8 ng/mL. The bioactivity of Y03801 was higher than other competing products.
Instructions for Use
- Dissolve the lyophilized powder in an appropriate sterile buffer in a sterile environment before use.
- Prepare and dilute the solution according to experimental requirements to ensure accurate and reproducible results.
- Do not mix with other similar products to avoid cross-reactivity and potential interference.
Cautions
• Research Use Only: This product is not suitable for clinical diagnostics or therapeutic applications.
• Preservation: Handle according to instructions to preserve its activity and stability.
• Support: Contact our technical support team if you encounter any issues or questions.
Documents
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
