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$79.00
Sku: Y01621H-10ug
Availability:
QUICK SHIP
In stock & estimated to ship in 1-2 days by June 06, 2026
Description
Recombinant Human Neuregulin-1 beta 1 (NRG1-β1) is a member of the neuregulin family of growth factors that plays a critical role in cell proliferation, differentiation, and survival. It functions by binding to ErbB receptor tyrosine kinases (ErbB3 and ErbB4), activating downstream signaling pathways such as PI3K/AKT and MAPK. NRG1-β1 is widely involved in cancer biology, neural development, and cell communication.
This recombinant protein is expressed in E. coli and corresponds to the functional region (S177–E241) of human NRG1-β1, retaining its biological activity. With high purity (≥95%) and validated bioactivity (ED50: 1–8 ng/mL in MCF-7 cell proliferation assay), this product is suitable for a wide range of applications in oncology and cell signaling research. The protein is supplied in a tag-free, lyophilized form for convenient storage and reconstitution.
Specifications
| Product Details | |
|---|---|
| Cat. No. | Y01621H |
| Purity | ≥95%, by SDS-PAGE (under reducing (R) & Non-reducing conditions, visualized by Coomassie staining). |
| Endotoxin | ≤10 EU/mg by the LAL method. |
| Bioactivity | Measured in a cell proliferation assay using MCF-7 breast cancer cell line.The ED50 for this effect is 1-8 ng/mL. |
| Accession | NP_039250 |
| Alternative Names | / |
| Species | Human |
| Expression System | E. coli |
| Mol. Weight | 7.5 kDa |
| Expression Region | S177-E241 |
| Tag Info | Tag free |
| Formulation | Lyophilized |
| Buffer | Lyophilized from a 0.22 μm-filtered solution containing 10 mM PB, 5% Trehalose and 0.01% Tween 80, pH7.4. |
| Size | 10μg/50μg/1mg |
| Lead Time | Products are in stock,but custom products may require further consultation. |
| Reconstitution | It is recommended to redissolve in sterile deionized water. |
| Shipping | The product is shipped with blue ice. |
| Storage & Stability | 36 months at -20°C to -80°C in lyophilized state;6 months at -20°C to -80°C under sterile conditions after reconstitution;7-10 days at 2°C to 8°C under sterile conditions after reconstitution;Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
Features
- ✔ High Purity: This product undergoes stringent purification processes, achieving a purity level of ≥95%, ensuring reliable and reproducible experimental results.
- ✔ High Biological Activity: Verified through multiple activity assays, this product effectively induces the expectedbiological responses in target cells.
- ✔ Optimized Expression System: Expressed in E. coli, enabling efficient production and suitability for routine laboratory applications.
- ✔ Convenient and Reliable: Supplied in a tag-free, lyophilized form for easy reconstitution, stable storage, and compatibility with various experimental workflows.
Applications
Neuroscience
Involved in neural development and cell communication, supporting research on nervous system function and disorders.
Cancer Research
Widely used in studies of tumor progression and signaling, especially in breast cancer models such as MCF-7 cells.
Cell Biology
Regulates cell proliferation, differentiation, and survival via ErbB receptor-mediated signaling pathways.
Data Figures
Figure 1: Measured in a cell inhibitionn assay using TF-1 cells at IL4 presence. The ED50 for this effect is ≤0.2 ng/mL. The bioactivity of Y07901 was higher than other competing products.
Instructions for Use
- Dissolve the lyophilized powder in an appropriate sterile buffer in a sterile environment before use.
- Prepare and dilute the solution according to experimental requirements to ensure accurate and reproducible results.
- Do not mix with other similar products to avoid cross-reactivity and potential interference.
Cautions
• Research Use Only: This product is not suitable for clinical diagnostics or therapeutic applications.
• Preservation: Handle according to instructions to preserve its activity and stability.
• Support: Contact our technical support team if you encounter any issues or questions.
Documents
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
