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$180.00
Sku: TL-642-0050
Availability:
QUICK SHIP
In stock & estimated to ship in 1-2 days by June 08, 2026
Description
Noggin is a secreted dimeric glycoprotein that is widely expressed in vertebrates and is highly conserved among different vertebrate species.
Noggin is a key regulator that modulates the formation of ectoderm-, mesoderm-, and endoderm-derived tissues and plays a critical role in bone development, joint formation, and neural tube closure.
Noggin regulates the BMP signaling pathway by binding to BMPs and preventing them from interacting with receptors.
As an antagonist of BMPs, Noggin inhibits chondrocyte proliferation and thus ensures proper joint formation.
When culturing human embryonic stem cells (hESCs) or neural stem cells under certain conditions, adding Noggin to antagonize BMP activity enables stem cells to proliferate while maintaining their undifferentiated state.
Specifications
| Parameter | Specification |
|---|---|
| Expression Host | CHO cells |
| Synonyms | Noggin; NOG; SYM1; SYNS1 |
| Protein Sequence | Amino acid sequence: Gln28–Cys232 of human Noggin (UniProt ID: Q13253) |
| Molecular Weight | Predicted molecular weight is 23.05 kDa |
| Purity | >95%, analyzed by SDS-PAGE |
| Endotoxin | <0.05 EU/μg |
| Purification Method | Chromatographic purification |
| Appearance | White lyophilized powder |
| Activity | Refer to COA for details |
Features
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CHO Cell–Expressed Human Noggin (Gln28–Cys232)
Recombinant human Noggin corresponding to Gln28–Cys232 produced in CHO cells with a predicted molecular weight of 23.05 kDa.
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High Purity Chromatographic Preparation
Purity >95% confirmed by SDS-PAGE analysis following chromatographic purification.
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Low Endotoxin Profile
Endotoxin level <0.05 EU/μg supporting sensitive in vitro cell culture applications.
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Defined Lyophilized Protein Format
Supplied as a white lyophilized powder with verified electrophoretic identity and consistent protein quality.
Application
BMP Signaling Antagonism Studies
Binds BMP family proteins and prevents receptor interaction, enabling investigation of BMP signaling pathways.
Stem Cell Culture Systems
Used in stem cell culture models including MSC and iPSC systems to modulate BMP signaling during cell expansion.
Embryonic Development Research
Applied in studies involving ectoderm-, mesoderm-, and endoderm-derived tissue formation and developmental biology.
Joint and Skeletal Development Models
Supports research on bone development, joint formation, and chondrocyte proliferation regulation.
Storage
Store below -20°C
Instructions
Centrifuge before reopening the tube. Dissolve the lyophilized protein in distilled water. It is recommended to reconstitute to a concentration greater than 100 μg /mL.
After reconstitution, the protein can be stored at -80℃ for 3-6 months and at 2-8℃ for 2-7 days. For optimal storage, aliquot the protein and minimize freeze-thaw cycles.
Precautions
This product is only suitable for in vitro cell culture and cannot be used directly in clinical treatment.
Documents
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
