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$300.00
Sku: Y06601H-50ug
Availability:
AVAILABLE
In stock & estimated to ship in 3-7 days by March 20, 2026
Description
IL-17A (Interleukin-17A) is a pro-inflammatory cytokine mainly produced by Th17 cells, as well as γδ T cells and innate lymphoid cells. It signals through the IL-17RA/IL-17RC receptor complex, activating NF-κB and MAPK pathways to induce inflammatory responses. Functionally, IL-17A promotes chemokine and cytokine production, drives neutrophil recruitment, and plays a key role in mucosal defense against extracellular bacteria and fungi. In in vitro cell and organoid models, IL-17A is commonly used to mimic inflammatory microenvironments and often acts synergistically with TNF-α or IL-22. Dysregulated IL-17A signaling is implicated in autoimmune and chronic inflammatory diseases such as psoriasis and inflammatory bowel disease.
Specifications
| Product Details | |
|---|---|
| Cat. No. | Y06601H |
| Purity | ≥95%, by SDS-PAGE (under reducing (R) & Non-reducing conditions, visualized by Coomassie staining). |
| Endotoxin | ≤10 EU/mg by the LAL method. |
| Bioactivity | Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells. The ED50 for this effect is＜10 ng/mL. |
| Accession | Q16552 |
| Species | Human |
| Expression System | CHO |
| Mol. Weight | 15.5 kDa |
| Expression Region | Ile20-Ala155 |
| Tag Info | Tag free |
| Form | Lyophilized |
| Buffer | Lyophilized from a 0.22 μm-filtered solution containing PBS, 5% Mannitol, 0.01% Tween 80, pH7.4. |
| Size | 10μg/50μg/1mg |
| Lead Time | Products are in stock, but custom products may require further consultation. |
| Reconstitution | It is recommended to redissolve in sterile deionized water. |
| Shipping | The product is shipped with blue ice. |
| Storage & Stability | 36 months at -20°C to-80°C in lyophilized state;6 months at -20°C to -80°C under sterile conditions after reconstitution;7-10 days at 2°C to 8°C under sterile conditions after reconstitution;Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
Features
- ✔ High Purity: This product undergoes stringent purification processes, achieving a purity level of over 95%,ensuring the reliability and reproducibility of experimental results.
- ✔ High Biological Activity: Verified through multiple activity assays, this product effectively induces the expectedbiological responses in target cells.
- ✔ Batch Consistency: Manufactured under strict production and quality control protocols to ensure highconsistency between batches.
- ✔ Animal-Free: Produced without the use of animal-derived components, meeting animal-free requirements.
Applications
Hematology
Involved in inflammation-related hematopoietic regulation.
Immunology
Signature Th17 cytokine driving chronic inflammation.
Cell Biology
Induces expression of inflammation-related genes.
Data Figures
Figure 1: Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells. The ED50 for this effect is＜10 ng/mL.
Instructions for Use
- Dissolve the lyophilized powder in an appropriate sterile buffer in a sterile environment before use.
- Prepare and dilute the solution according to experimental requirements to ensure accurate and reproducible results.
- Do not mix with other similar products to avoid cross-reactivity and potential interference.
Cautions
• Research Use Only: This product is not suitable for clinical diagnostics or therapeutic applications.
• Preservation: Handle according to instructions to preserve its activity and stability.
• Support: Contact our technical support team if you encounter any issues or questions.
Documents
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
