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$350.00
Sku: TL-771-0050
Availability:
QUICK SHIP
In stock & estimated to ship in 1-2 days by March 13, 2026
Description
Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor belonging to the transforming growth factor-beta (TGF-β) superfamily.
It is expressed in various brain regions, including the hippocampus, amygdala, cerebral cortex, and cerebellum, and is involved in the growth and morphological regulation of dopaminergic neuronal projections.
GDNF supports the survival and maintenance of several neuronal populations, including sensory neurons, retinal ganglion cells, cholinergic neurons, and spinal motor neurons, making it a potential therapeutic agent for neurodegenerative diseases.
Specifications
| Parameter | Specification |
|---|---|
| Expression Host | E. coli |
| Synonyms | Glial cell line-derived neurotrophic factor; hGDNF; Astrocyte-derived trophic factor (ATF) |
| Protein Sequence | Amino acid sequence: Ser78–Ile211 of human GDNF (UniProt ID: P39905-1) |
| Molecular Weight | Predicted molecular weight is 15.06 kDa |
| Purity | >95%, analyzed by SDS-PAGE gel and HPLC |
| Endotoxin | <0.1 EU/μg |
| Purification Method | Chromatographic purification |
| Appearance | White lyophilized powder |
| Activity | Refer to COA for details |
Features
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E. coli–Expressed Human GDNF (Ser78–Ile211)
Recombinant human GDNF corresponding to Ser78–Ile211 expressed in E. coli, with a predicted molecular weight of 15.06 kDa.
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High Purity Chromatographic Preparation
Purity >95% verified by SDS-PAGE gel and HPLC following chromatographic purification.
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Low Endotoxin Profile
Endotoxin level <0.1 EU/μg suitable for sensitive in vitro cell culture systems.
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Defined Lyophilized Protein Format
Supplied as a white lyophilized powder with verified electrophoretic identity and consistent protein quality.
Applications
Neurotrophic Factor Research
Supports studies on neuronal survival, maintenance, and development of dopaminergic neuronal projections.
Neurodegenerative Disease Models
Applied in research involving neuronal populations such as sensory neurons, retinal ganglion cells, cholinergic neurons, and spinal motor neurons.
Stem Cell Culture Studies
Used in stem cell-related experiments including MSC and iPSC culture systems.
Neuronal Differentiation Studies
Facilitates investigations into neuronal growth and morphological regulation in neural cell culture models.
Storage
Store below -20°C
Instructions
Centrifuge before reopening the tube. Dissolve the lyophilized protein in distilled water. It is recommended to reconstitute the concentration to greater than 100 μg /mL. After reconstitution, the protein can be stored at -80°C for 3-6 months and at 2-8℃ for 2-7 days. For optimal storage, aliquot the protein and minimize freeze-thaw cycles.
Precautions
This product is only suitable for in vitro cell culture and cannot be used directly in clinical treatment.
Documents
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
