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$408.00
Sku: Y00921H-50ug
Availability:
AVAILABLE
In stock & estimated to ship in 3-7 days by March 20, 2026
Description
FGF-4 (Fibroblast Growth Factor 4), a member of the FGF family, is a secreted glycoprotein that activates downstream signaling pathways (such as MAPK and PI3K-AKT) by binding to its receptors (FGFRs). It promotes cell proliferation, differentiation, migration, and survival, playing a central role in embryonic development, mesoderm formation, and stem cell maintenance. In stem cells, it helps maintain pluripotency; for example, FGF-4 and LIF (Leukemia Inhibitory Factor) act synergistically to sustain the undifferentiated state of mouse embryonic stem cells (ESCs). Additionally, FGF-4 can promote the differentiation of specific cell types and is used in the culture of primary cells.
Specifications
| Product Details | |
|---|---|
| Cat. No. | Y00921H |
| Purity | ≥95%, by SDS-PAGE (under conditions, visualized by Coomassie staining). |
| Endotoxin | ≤10 EU/mg by the LAL method. |
| Bioactivity | Measured in a cell proliferation assay using NIH3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 0.25-1 ng/mL. |
| Accssion | P08620 |
| Alternative Names | Fibroblast growth factor 4; FGF-4; Heparin secretory-transforming protein 1; HST; HST-1; HSTF-1; Heparin-binding growth factor 4; HBGF-4; Transforming protein KS3; FGF4; HST; HSTF1; KS3 |
| Species | Human |
| Expression System | E. coli |
| Mol. Weight | 19.3 kDa |
| Expression Region | Ala31-Leu206 |
| Tag Info | Tag free |
| Formulation | Lyophilized |
| Buffer | PBS, 5% Mannitol and 0.01% Tween 80, pH7.4. |
| Size | 50μg/1mg |
| Lead Time | Products are in stock, but custom products may require further consultation. |
| Reconstitution | It is recommended to redissolve in sterile deionized water. |
| Shipping | The product is shipped with blue ice. |
| Storage & Stability | 36 months at -20°C to -80°C in lyophilized state;6 months at -20°C to -80°C under sterile conditions after reconstitution;7-10 days at 2°C to 8°C under sterile conditions after reconstitution;Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
Features
- ✔ High Purity: This product undergoes stringent purification processes, achieving a purity level of over 95%,ensuring the reliability and reproducibility of experimental results.
- ✔ High Biological Activity: Verified through multiple activity assays, this product effectively induces the expectedbiological responses in target cells.
- ✔ Batch Consistency: Manufactured under strict production and quality control protocols to ensure highconsistency between batches.
- ✔ Animal-Free: Produced without the use of animal-derived components, meeting animal-free requirements.
Applications
Stem Cell Research
Supports ESC proliferation and survival, especially in combination with FGF-2 for pluripotent stem cells.
Cell Biology
Involved in early embryonic development signaling and cell proliferation.
Data Figures
Figure 1: Recombinant Human FGF4 (Cat. No. Y00901) SDS-PAGE under reducing (R) & Non-reducing conditions. The gel was stained with Y00901 SDS-PAGE.
Figure 2: Recombinant Human FGF4 (Cat. No. Y00901) stimulates proliferation of NIH3T3 cells. The ED50 for this effect is 0.25-1 ng/mL. The bioactivity of Y00901 was higher than the other competing product.
Instructions for Use
- Dissolve the lyophilized powder in an appropriate sterile buffer in a sterile environment before use.
- Prepare and dilute the solution according to experimental requirements to ensure accurate and reproducible results.
- Do not mix with other similar products to avoid cross-reactivity and potential interference.
Cautions
• Research Use Only: This product is not suitable for clinical diagnostics or therapeutic applications.
• Preservation: Handle according to instructions to preserve its activity and stability.
• Support: Contact our technical support team if you encounter any issues or questions.
Documents
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
