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$192.00
Sku: Y05801-50ug
Availability:
AVAILABLE
In stock & estimated to ship in 3-7 days by March 20, 2026
Description
EPO (Erythropoietin), also known as erythrocyte-stimulating factor, is an endogenous glycoprotein hormone composed of 165 amino acids. During the fetal period, EPO is primarily produced in the liver, while after birth its synthesis occurs mainly in the kidneys. Additionally, the liver, brain, reproductive system, bone marrow macrophages, and mammary glands also have the capacity to produce EPO autonomously. Its synthesis is regulated by hypoxia-inducible factors (HIFs), among other mechanisms. As an important cytokine in humans, the most well-known and essential biological function of EPO is to stimulate erythrocyte proliferation and promote hematopoiesis. Beyond its role in blood formation, EPO also exhibits other effects, such as inhibiting pro-inflammatory cytokines, protecting cells from apoptosis, and promoting angiogenesis in both normal and tumor tissues.
Specifications
| Product Details | |
|---|---|
| Cat. No. | Y05801 |
| Purity | ≥95%, by SDS-PAGE (under reducing (R) & Non-reducing conditions, visualized by Coomassie staining). |
| Endotoxin | ≤10 EU/mg by the LAL method. |
| Bioactivity | Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is ≤0.1 ng/mL. |
| Accession | P01588 |
| Alternative Names | Erythropoietin; Epoetin; EPO |
| Species | Human |
| Expression System | CHO |
| Mol. Weight | 18.3 kDa |
| Expression Region | Ala28-Arg193 |
| Tag Info | Tag free |
| Formulation | Lyophilized |
| Buffer | Lyophilized from a 0.22 μm-filtered solution containing PBS, 5% Mannitol and 0.01% Tween 80, pH7.4. |
| Size | 10μg/50μg/1mg |
| Lead Time | Products are in stock, but custom products may require further consultation. |
| Reconstitution | It is recommended to redissolve in sterile deionized water. |
| Shipping | The product is shipped with blue ice. |
| Storage & Stability | 36 months at -20°C to -80°C in lyophilized state;6 months at -20°C to -80°C under sterile conditions after reconstitution;7-10 days at 2°C to 8°C under sterile conditions after reconstitution;Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
Features
- ✔ High Purity: This product undergoes stringent purification processes, achieving a purity level of over 95%,ensuring the reliability and reproducibility of experimental results.
- ✔ High Biological Activity: Verified through multiple activity assays, this product effectively induces the expectedbiological responses in target cells.
- ✔ Batch Consistency: Manufactured under strict production and quality control protocols to ensure highconsistency between batches.
- ✔ Animal-Free: Produced without the use of animal-derived components, meeting animal-free requirements.
Applications
Hematology
Stimulates erythroid progenitor proliferation and differentiation.
Immunology
Modulates immune cell function and inflammation indirectly.
Stem Cell Research
Used to promote hematopoietic lineage commitment in stem cell cultures.
Cell Biology
Regulates erythropoiesis and cell survival via JAK2/STAT5 signaling.
Data Figures
Figure 1: Recombinant Human EPO (Cat. No. Y05801) SDS-PAGE under reducing (R) & Non-reducing conditions. The gel was stained with Y05801 SDS-PAGE.
Figure 2: Recombinant Human EPO (Cat. No.Y05801) stimulates proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is ≤0.1 ng/mL.
Instructions for Use
- Dissolve the lyophilized powder in an appropriate sterile buffer in a sterile environment before use.
- Prepare and dilute the solution according to experimental requirements to ensure accurate and reproducible results.
- Do not mix with other similar products to avoid cross-reactivity and potential interference.
Cautions
• Research Use Only: This product is not suitable for clinical diagnostics or therapeutic applications.
• Preservation: Handle according to instructions to preserve its activity and stability.
• Support: Contact our technical support team if you encounter any issues or questions.
Documents
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
