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$272.00
Sku: Y05621H-50ug
Availability:
AVAILABLE
In stock & estimated to ship in 3-7 days by March 20, 2026
Description
CNTF (Ciliary Neurotrophic Factor) is a neurotrophic factor structurally similar to IL-6 and LIF, featuring a characteristic four-helix bundle topology. It was initially identified based on its ability to support neuronal survival, particularly in the ciliary ganglion. CNTF promotes the survival of various types of neurons, including sympathetic, sensory, motor, and hippocampal neurons. It also induces the proliferation and differentiation of astrocytes and stimulates the secretion of other neurotrophic factors. Furthermore, when used in combination with EGF/bFGF, CNTF can induce the differentiation of neural stem cells into neurons or glial cells.
Specifications
| Product Details | |
|---|---|
| Cat. No. | Y05621H |
| Purity | ≥95% |
| Endotoxin | ≤10 EU/mg by the LAL method. |
| Bioactivity | Measured in a cell proliferation assay using TF-1 cells. The ED50 is ＜100 pg/ml. |
| Accession | NP_000605.1 |
| Species | Human |
| Expression System | E. coli |
| Mol. Weight | 22.9 kDa |
| Expression Region | M1-M200 |
| Tag Info | Tag free |
| Formulation | Lyophilized |
| Buffer | Lyophilized from a 0.22 μm-filtered solution containing 20mM Citric acid, 5% Mannitol and 0.01% Tween 80, pH2.5. |
| Size | 10μg/50μg |
| Lead Time | Products are in stock, but custom products may require further consultation. |
| Reconstitution | It is recommended to redissolve in sterile deionized water. |
| Shipping | The product is shipped with blue ice. |
| Storage & Stability | 36 months at -20°C to -80°C in lyophilized state;6 months at -20°C to -80°C under sterile conditions after reconstitution;7-10 days at 2°C to 8°C under sterile conditions after reconstitution;Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
Features
- ✔ High Purity: This product undergoes stringent purification processes, achieving a purity level of over 95%,ensuring the reliability and reproducibility of experimental results.
- ✔ High Biological Activity: Verified through multiple activity assays, this product effectively induces the expectedbiological responses in target cells.
- ✔ Batch Consistency: Manufactured under strict production and quality control protocols to ensure highconsistency between batches.
- ✔ Animal-Free: Produced without the use of animal-derived components, meeting animal-free requirements.
Applications
Stem Cell Research
Promotes neural stem/progenitor cell survival and differentiation.
Cell Biology
Enhances neuronal survival and differentiation through JAK/STAT signaling.
Data Figures
Figure 1: Measured in a cell proliferation assay using TF-1 cells.
Instructions for Use
- Dissolve the lyophilized powder in an appropriate sterile buffer in a sterile environment before use.
- Prepare and dilute the solution according to experimental requirements to ensure accurate and reproducible results.
- Do not mix with other similar products to avoid cross-reactivity and potential interference.
Cautions
• Research Use Only: This product is not suitable for clinical diagnostics or therapeutic applications.
• Preservation: Handle according to instructions to preserve its activity and stability.
• Support: Contact our technical support team if you encounter any issues or questions.
Documents
When can I expect my order to ship?
Most orders are filled and shipped within 2-3 business days from the time they are received.
Our standard shipping usually take 2-5 days.
We also provide express shippping for time-sensitive deliveries.
Email contact@biofargo.com if you have any requirements.
