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Full name | RAD50 rabbit monoclonal antibody |
Alternative names | 50 μl/100 μl |
Reactivity | rabbit monoclonal |
Applications | WB, IHC |
Host | Rabbit |
Clone type | rabbit monoclonal |
Target Background | The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010] |
Swissprot No | Q92878 |
Gene Accession | 10111 |
WB Predicted band size | |
WB Positive control | P291300-WB-1-P |
WB Recommended dilution | 154 kDa |
IHC predicted cell location | Predicted cell location: Nucleus |
IHC positive control | Positive control: Human cholangiocarcinoma |
IHC Recommed dilution | Recommended dilution: 50-100 |
-20°C, 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA. Avoid repeated freeze-thaw cycles.
P291300-WB-1-P
Immunohistochemical analysis of paraffin-embedded Human cholangiocarcinoma tissue using P291300(RAD50 Antibody) at dilution 1/50
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