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Specification
| Full name | RAB3A rabbit polyclonal antibody |
| Alternative names | 50 μl/100 μl |
| Reactivity | rabbit polyclonal |
| Applications | WB, IHC |
| Host | Rabbit |
| Clone type | rabbit polyclonal |
| Target Background | Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity). Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity). Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (PubMed:27325790). Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (PubMed:22248876, PubMed:30599141). Plays also a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity). |
| Swissprot No | P20336 |
| Gene Accession | BC011782 |
| WB Predicted band size | Immunohistochemical analysis of paraffin-embedded Human brain tissue or RAB3A antigen-treated (Neutralization experiment) using P113501(RAB3A Antibody) at dilution 1/110 |
| WB Positive control | P113501-WB-1-P |
| WB Recommended dilution | 25 kDa |
| IHC predicted cell location | Predicted cell location: Cytoplasm |
| IHC positive control | Positive control: Human esophagus cancer |
| IHC Recommed dilution | Recommended dilution: 100-300 |
Storage
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
WB PIC Description
P113501-WB-1-P
IHC PIC Description
Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue or RAB3A antigen-treated (Neutralization experiment) using P113501(RAB3A Antibody) at dilution 1/110
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