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Specification
| Full name | PTBP1 rabbit polyclonal antibody |
| Alternative names | 50 μl/100 μl |
| Reactivity | rabbit polyclonal |
| Applications | WB, IHC |
| Host | Rabbit |
| Clone type | rabbit polyclonal |
| Target Background | This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. |
| Swissprot No | P26599 |
| Gene Accession | BC004383 |
| WB Predicted band size | Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue or PTBP1 antigen-treated (Neutralization experiment) using P114739(PTBP1 Antibody) at dilution 1/70 |
| WB Positive control | P114739-WB-1-P |
| WB Recommended dilution | 57 kDa |
| IHC predicted cell location | Predicted cell location: Nucleus |
| IHC positive control | Positive control: Human colorectal cancer |
| IHC Recommed dilution | Recommended dilution: 50-200 |
Storage
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
WB PIC Description
P114739-WB-1-P
IHC PIC Description
Immunohistochemical analysis of paraffin-embedded Human colorectal cancer tissue or PTBP1 antigen-treated (Neutralization experiment) using P114739(PTBP1 Antibody) at dilution 1/70
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