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Specification
| Full name | PRKAR2A rabbit polyclonal antibody |
| Alternative names | 50 μl/100 μl |
| Reactivity | rabbit polyclonal |
| Applications | WB, IHC |
| Host | Rabbit |
| Clone type | rabbit polyclonal |
| Target Background | cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). |
| Swissprot No | P13861 |
| Gene Accession | BC002763 |
| WB Predicted band size | Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue or PRKAR2A antigen-treated (Neutralization experiment) using P101070(PRKAR2A Antibody) at dilution 1/50 |
| WB Positive control | P101070-WB-1-P |
| WB Recommended dilution | 46 kDa |
| IHC predicted cell location | Predicted cell location: Cytoplasm and Cell membrane |
| IHC positive control | Positive control: Human breast cancer |
| IHC Recommed dilution | Recommended dilution: 35-200 |
Storage
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
WB PIC Description
P101070-WB-1-P
IHC PIC Description
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue or PRKAR2A antigen-treated (Neutralization experiment) using P101070(PRKAR2A Antibody) at dilution 1/50
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We also provide express shippping for time-sensitive deliveries.
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