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Specification
| Full name | PAX5 rabbit polyclonal antibody |
| Alternative names | 50 μl/100 μl |
| Reactivity | rabbit polyclonal |
| Applications | WB, IHC |
| Host | Rabbit |
| Clone type | rabbit polyclonal |
| Target Background | This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Swissprot No | Q02548 |
| Gene Accession | NP_057953 |
| WB Predicted band size | Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue or PAX5 antigen-treated (Neutralization experiment) using P102320(PAX5 Antibody) at dilution 1/40 |
| WB Positive control | P102320-WB-1-P |
| WB Recommended dilution | 42 kDa |
| IHC predicted cell location | Predicted cell location: Nucleus |
| IHC positive control | Positive control: Human tonsil |
| IHC Recommed dilution | Recommended dilution: 30-150 |
Storage
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
WB PIC Description
P102320-WB-1-P
IHC PIC Description
Immunohistochemical analysis of paraffin-embedded Human tonsil tissue or PAX5 antigen-treated (Neutralization experiment) using P102320(PAX5 Antibody) at dilution 1/40
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