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Sku: P102320-50 μl

Specification

Full name PAX5 rabbit polyclonal antibody
Alternative names 50 μl/100 μl
Reactivity rabbit polyclonal
Applications WB, IHC
Host Rabbit
Clone type rabbit polyclonal
Target Background This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms.
Swissprot No Q02548
Gene Accession NP_057953
WB Predicted band size Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue or PAX5 antigen-treated (Neutralization experiment) using P102320(PAX5 Antibody) at dilution 1/40
WB Positive control P102320-WB-1-P
WB Recommended dilution 42 kDa
IHC predicted cell location Predicted cell location: Nucleus
IHC positive control Positive control: Human tonsil
IHC Recommed dilution Recommended dilution: 30-150

Storage

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

WB PIC Description

P102320-WB-1-P

IHC PIC Description

Immunohistochemical analysis of paraffin-embedded Human tonsil tissue or PAX5 antigen-treated (Neutralization experiment) using P102320(PAX5 Antibody) at dilution 1/40

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