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Specification
| Full name | PAK1/PAK2/PAK3 (phospho-Ser144/Ser141/Ser154) rabbit monoclonal antibody |
| Alternative names | 50 μl/100 μl |
| Reactivity | rabbit monoclonal |
| Applications | WB, IF |
| Host | Rabbit |
| Clone type | rabbit monoclonal |
| Target Background | The PAK1 gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Mutations in this gene have been associated with macrocephaly, seizures, and speech delay. Overexpression of this gene is also reported in many cancer types, and particularly in breast cancer. Alternative splicing results in multiple transcript variants. The protein encoded by the PAK2 gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. The protein encoded by the PAK3 gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of a non-syndromic form of X-linked intellectual disability. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| Swissprot No | Q13153/Q13177/O75914 |
| Gene Accession | 5058/5062/5063 |
| WB Predicted band size | |
| WB Positive control | P291103-WB-1-P |
| WB Recommended dilution | 62 kDa |
| IHC predicted cell location | |
| IHC positive control | |
| IHC Recommed dilution |
Storage
-20°C, 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA. Avoid repeated freeze-thaw cycles.
WB PIC Description
P291103-WB-1-P
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