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Sku: P102438-50 μl

Specification

Full name NOTCH1 rabbit polyclonal antibody
Alternative names 50 μl/100 μl
Reactivity rabbit polyclonal
Applications WB, IHC
Host Rabbit
Clone type rabbit polyclonal
Target Background This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.
Swissprot No P46531
Gene Accession NP_060087
WB Predicted band size Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue or NOTCH1 antigen-treated (Neutralization experiment) using P102438(NOTCH1 Antibody) at dilution 1/50
WB Positive control P102438-WB-1-P
WB Recommended dilution 272 kDa
IHC predicted cell location Predicted cell location: Cytoplasm and Nucleus
IHC positive control Positive control: Human gastric cancer
IHC Recommed dilution Recommended dilution: 50-200

Storage

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

WB PIC Description

P102438-WB-1-P

IHC PIC Description

Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue or NOTCH1 antigen-treated (Neutralization experiment) using P102438(NOTCH1 Antibody) at dilution 1/50

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