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Description
Nicotinamide (NAM) belongs to vitamin B family and is the amide form of vitamin B3. NAM is present in food and is a constituent of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Tryptophan is the precursor for NAM synthesis in liver.[1] NAM controls cell metabolism, redox reactions, mitochondrial functionsand energy generation. It promotes natural killer cells proliferation and survival.[2] NAM confers neuroprotection and promotes neuronal maturation. It has the ability to cross the blood-brain barrier and may provide protection in ischaemic stroke and traumatic brain injury. NAM may elicit therapeutic benefits in Alzheimer′s, Parkinson′s, and Huntington′s diseases.
Specification
| Grade | Reagent |
| Formula | C6H6N2O |
| MW | 122.1 |
| CAS | 98-92-0 |
| Appearance | White crystalline or powder |
| Identification | Complies |
| Melting Point | 128 - 131℃ |
| Loss on Drying | ≤0.5% |
| Residue on ignition | ≤0.1% |
| Heavy Metals | ≤0.003% |
| Readily carbonizable substances | ≤ Control Solution A |
| Organic volatile impurities | Complies |
| Residual solvents | Complies |
| Assay | 98.5-101.5% |
| Storage | 18~25℃ |
Application
Nicotinamide has been used as a medium supplement in organoid culture of intestinal stem cells, esophageal squamous cell carcinomas(ESCC), pancreatic cancer organoids and pancreatic progenitor induction.
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