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Specification
| Full name | MAPKAPK3 rabbit polyclonal antibody |
| Alternative names | 50 μl/100 μl |
| Reactivity | rabbit polyclonal |
| Applications | WB, IHC |
| Host | Rabbit |
| Clone type | rabbit polyclonal |
| Target Background | This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. |
| Swissprot No | Q16644 |
| Gene Accession | BC001662 |
| WB Predicted band size | Immunohistochemical analysis of paraffin-embedded Human brain tissue or MAPKAPK3 antigen-treated (Neutralization experiment) using P113576(MAPKAPK3 Antibody) at dilution 1/95 |
| WB Positive control | P113576-WB-1-P |
| WB Recommended dilution | 43 kDa |
| IHC predicted cell location | Predicted cell location: Cytoplasm |
| IHC positive control | Positive control: Human colorectal cancer |
| IHC Recommed dilution | Recommended dilution: 100-300 |
Storage
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
WB PIC Description
P113576-WB-1-P
IHC PIC Description
Immunohistochemical analysis of paraffin-embedded Human colorectal cancer tissue or MAPKAPK3 antigen-treated (Neutralization experiment) using P113576(MAPKAPK3 Antibody) at dilution 1/95
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