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Specification
| Full name | MAP2K2 rabbit polyclonal antibody |
| Alternative names | 50 μl/100 μl |
| Reactivity | rabbit polyclonal |
| Applications | WB, IHC |
| Host | Rabbit |
| Clone type | rabbit polyclonal |
| Target Background | The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. |
| Swissprot No | P36507 |
| Gene Accession | NP_109587 |
| WB Predicted band size | Immunohistochemical analysis of paraffin-embedded Human ovarian cancer tissue or MAP2K2 antigen-treated (Neutralization experiment) using P102273(MAP2K2 Antibody) at dilution 1/100 |
| WB Positive control | P102273-WB-1-P |
| WB Recommended dilution | 44 kDa |
| IHC predicted cell location | Predicted cell location: Cytoplasm |
| IHC positive control | Positive control: Human gasrtic cancer |
| IHC Recommed dilution | Recommended dilution: 100-300 |
Storage
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
WB PIC Description
P102273-WB-1-P
IHC PIC Description
Immunohistochemical analysis of paraffin-embedded Human gasrtic cancer tissue or MAP2K2 antigen-treated (Neutralization experiment) using P102273(MAP2K2 Antibody) at dilution 1/100
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