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Full name | MAP2K2 mouse monoclnal antibody |
Alternative names | 50 μl/100 μl |
Reactivity | mouse monoclonal |
Applications | WB |
Host | Mouse |
Clone type | mouse monoclonal |
Target Background | The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. |
Swissprot No | P36507 |
Gene Accession | |
WB Predicted band size | |
WB Positive control | P114229-WB-1-P |
WB Recommended dilution | 44 kDa |
IHC predicted cell location | |
IHC positive control | |
IHC Recommed dilution |
Ascitic fluid with 0.05% sodium azide and 40% glycerol
P114229-WB-1-P
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