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DGSX; Glypican 3; glypican proteoglycan 3; glypican-3; GPC3; GTR2-2; heparan sulphate proteoglycan; Intestinal protein OCI-5; MXR7; OCI5; OCI-5; secreted glypican-3; SGB; SGBS; SGBS1SDYS
$198.00
Sku: RP603-10UG
GPC (glypicans) are a family of heparan sulfate proteoglycans that are attached to the cell surface by a glycosylphosphatidylinositol anchor. Mutations in GPC3 cause a rare disorder in humans, Simpson-Golabi-Behmel Syndrome. Glypican 3 has been implicated in regulating many different signaling pathways including: IGF, FGF, BMP and Wnt, but it is required for an endoproteolytic processing of GPC3 for the modulation of Wnt signaling (1-5).
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