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Full name | HRAS rabbit polyclonal antibody |
Alternative names | 50 μl/100 μl |
Reactivity | rabbit polyclonal |
Applications | WB, IHC |
Host | Rabbit |
Clone type | rabbit polyclonal |
Target Background | This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. |
Swissprot No | P01112 |
Gene Accession | NP_005334 |
WB Predicted band size | |
WB Positive control | P114344-WB-1-P |
WB Recommended dilution | 21 kDa |
IHC predicted cell location | Predicted cell location: Nucleus |
IHC positive control | Positive control: Human colorectal cancer |
IHC Recommed dilution | Recommended dilution: 100-300 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
P114344-WB-1-P
Immunohistochemical analysis of paraffin-embedded Human colorectal cancer tissue or HRAS antigen-treated (Neutralization experiment) using P114344(HRAS Antibody) at dilution 1/50
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