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Full name | HEXB rabbit polyclonal antibody |
Alternative names | 50 μl/100 μl |
Reactivity | rabbit polyclonal |
Applications | WB, IHC |
Host | Rabbit |
Clone type | rabbit polyclonal |
Target Background | Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Swissprot No | P07686 |
Gene Accession | NP_000512 |
WB Predicted band size | Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue or HEXB antigen-treated (Neutralization experiment) using P114216(HEXB Antibody) at dilution 1/50 |
WB Positive control | P114216-WB-1-P |
WB Recommended dilution | 63 kDa |
IHC predicted cell location | Predicted cell location: Cytoplasm |
IHC positive control | Positive control: Human cervical cancer |
IHC Recommed dilution | Recommended dilution: 50-200 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
P114216-WB-1-P
Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue or HEXB antigen-treated (Neutralization experiment) using P114216(HEXB Antibody) at dilution 1/50
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