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Sku: P114216-50 μl

Specification

Full name HEXB rabbit polyclonal antibody
Alternative names 50 μl/100 μl
Reactivity rabbit polyclonal
Applications WB, IHC
Host Rabbit
Clone type rabbit polyclonal
Target Background Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Swissprot No P07686
Gene Accession NP_000512
WB Predicted band size Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue or HEXB antigen-treated (Neutralization experiment) using P114216(HEXB Antibody) at dilution 1/50
WB Positive control P114216-WB-1-P
WB Recommended dilution 63 kDa
IHC predicted cell location Predicted cell location: Cytoplasm
IHC positive control Positive control: Human cervical cancer
IHC Recommed dilution Recommended dilution: 50-200

Storage

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

WB PIC Description

P114216-WB-1-P

IHC PIC Description

Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue or HEXB antigen-treated (Neutralization experiment) using P114216(HEXB Antibody) at dilution 1/50

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