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Sku: P290601-50 μl

Specification

Full name GRIA2 rabbit monoclonal antibody
Alternative names 50 μl/100 μl
Reactivity rabbit monoclonal
Applications WB, IHC
Host Rabbit
Clone type rabbit monoclonal
Target Background Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
Swissprot No P42262
Gene Accession 2891
WB Predicted band size
WB Positive control P290601-WB-1-P
WB Recommended dilution 99 kDa
IHC predicted cell location Predicted cell location: Cytoplasm
IHC positive control Positive control: Human breast cancer
IHC Recommed dilution Recommended dilution: 50-100

Storage

-20°C, 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA. Avoid repeated freeze-thaw cycles.

WB PIC Description

P290601-WB-1-P

IHC PIC Description

Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using P290601(GRIA2 Antibody) at dilution 1/50

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