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Sku: P111487-50 μl
Categories: Primary Antibodies

Specification

Full name ECD rabbit polyclonal antibody
Alternative names 50 μl/100 μl
Reactivity rabbit polyclonal
Applications WB, IHC
Host Rabbit
Clone type rabbit polyclonal
Target Background Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212).
Swissprot No O95905
Gene Accession BC000721
WB Predicted band size Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue or ECD antigen-treated (Neutralization experiment) using P111487(ECD Antibody) at dilution 1/35
WB Positive control P111487-WB-1-P
WB Recommended dilution 73 kDa
IHC predicted cell location Predicted cell location: Cytoplasm or Nucleus
IHC positive control Positive control: Human cervical cancer
IHC Recommed dilution Recommended dilution: 25-100

Storage

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

WB PIC Description

P111487-WB-1-P

IHC PIC Description

Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue or ECD antigen-treated (Neutralization experiment) using P111487(ECD Antibody) at dilution 1/35

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