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Specification
| Full name | ECD rabbit polyclonal antibody |
| Alternative names | 50 μl/100 μl |
| Reactivity | rabbit polyclonal |
| Applications | WB, IHC |
| Host | Rabbit |
| Clone type | rabbit polyclonal |
| Target Background | Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212). |
| Swissprot No | O95905 |
| Gene Accession | BC000721 |
| WB Predicted band size | Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue or ECD antigen-treated (Neutralization experiment) using P111487(ECD Antibody) at dilution 1/35 |
| WB Positive control | P111487-WB-1-P |
| WB Recommended dilution | 73 kDa |
| IHC predicted cell location | Predicted cell location: Cytoplasm or Nucleus |
| IHC positive control | Positive control: Human cervical cancer |
| IHC Recommed dilution | Recommended dilution: 25-100 |
Storage
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
WB PIC Description
P111487-WB-1-P
IHC PIC Description
Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue or ECD antigen-treated (Neutralization experiment) using P111487(ECD Antibody) at dilution 1/35
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