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Specification
| Full name | DYRK1A rabbit polyclonal antibody |
| Alternative names | 50 μl/100 μl |
| Reactivity | rabbit polyclonal |
| Applications | WB, IHC |
| Host | Rabbit |
| Clone type | rabbit polyclonal |
| Target Background | This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. |
| Swissprot No | Q13627 |
| Gene Accession | NP_001387 |
| WB Predicted band size | Immunohistochemical analysis of paraffin-embedded Human ovarian cancer tissue or DYRK1A antigen-treated (Neutralization experiment) using P111221(DYRK1A Antibody) at dilution 1/30 |
| WB Positive control | P111221-WB-1-P |
| WB Recommended dilution | 85 kDa |
| IHC predicted cell location | Predicted cell location: Cytoplasm or Nucleus |
| IHC positive control | Positive control: Human liver cancer |
| IHC Recommed dilution | Recommended dilution: 25-100 |
Storage
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
WB PIC Description
P111221-WB-1-P
IHC PIC Description
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue or DYRK1A antigen-treated (Neutralization experiment) using P111221(DYRK1A Antibody) at dilution 1/30
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