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Sku: P111221-50 μl

Specification

Full name DYRK1A rabbit polyclonal antibody
Alternative names 50 μl/100 μl
Reactivity rabbit polyclonal
Applications WB, IHC
Host Rabbit
Clone type rabbit polyclonal
Target Background This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.
Swissprot No Q13627
Gene Accession NP_001387
WB Predicted band size Immunohistochemical analysis of paraffin-embedded Human ovarian cancer tissue or DYRK1A antigen-treated (Neutralization experiment) using P111221(DYRK1A Antibody) at dilution 1/30
WB Positive control P111221-WB-1-P
WB Recommended dilution 85 kDa
IHC predicted cell location Predicted cell location: Cytoplasm or Nucleus
IHC positive control Positive control: Human liver cancer
IHC Recommed dilution Recommended dilution: 25-100

Storage

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

WB PIC Description

P111221-WB-1-P

IHC PIC Description

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue or DYRK1A antigen-treated (Neutralization experiment) using P111221(DYRK1A Antibody) at dilution 1/30

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