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Full name | DHCR7 rabbit polyclonal antibody |
Alternative names | 50 μl/100 μl |
Reactivity | rabbit polyclonal |
Applications | WB, IHC |
Host | Rabbit |
Clone type | rabbit polyclonal |
Target Background | This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by cognitive disability, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein. |
Swissprot No | Q9UBM7 |
Gene Accession | BC000054 |
WB Predicted band size | Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue or DHCR7 antigen-treated (Neutralization experiment) using P105148(DHCR7 Antibody) at dilution 1/80 |
WB Positive control | P105148-WB-1-P |
WB Recommended dilution | 54 kDa |
IHC predicted cell location | Predicted cell location: Cytoplasm |
IHC positive control | Positive control: Human thyroid cancer |
IHC Recommed dilution | Recommended dilution: 50-200 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
P105148-WB-1-P
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue or DHCR7 antigen-treated (Neutralization experiment) using P105148(DHCR7 Antibody) at dilution 1/80
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