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Sku: P105148-50 μl

Specification

Full name DHCR7 rabbit polyclonal antibody
Alternative names 50 μl/100 μl
Reactivity rabbit polyclonal
Applications WB, IHC
Host Rabbit
Clone type rabbit polyclonal
Target Background This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by cognitive disability, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.
Swissprot No Q9UBM7
Gene Accession BC000054
WB Predicted band size Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue or DHCR7 antigen-treated (Neutralization experiment) using P105148(DHCR7 Antibody) at dilution 1/80
WB Positive control P105148-WB-1-P
WB Recommended dilution 54 kDa
IHC predicted cell location Predicted cell location: Cytoplasm
IHC positive control Positive control: Human thyroid cancer
IHC Recommed dilution Recommended dilution: 50-200

Storage

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

WB PIC Description

P105148-WB-1-P

IHC PIC Description

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue or DHCR7 antigen-treated (Neutralization experiment) using P105148(DHCR7 Antibody) at dilution 1/80

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