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Specification
| Full name | COX7A2L rabbit polyclonal antibody |
| Alternative names | 50 μl/100 μl |
| Reactivity | rabbit polyclonal |
| Applications | WB, IHC |
| Host | Rabbit |
| Clone type | rabbit polyclonal |
| Target Background | Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. |
| Swissprot No | O14548 |
| Gene Accession | BC007095 |
| WB Predicted band size | Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue or COX7A2L antigen-treated (Neutralization experiment) using P103377(COX7A2L Antibody) at dilution 1/65 |
| WB Positive control | P103377-WB-1-P |
| WB Recommended dilution | 13 kDa |
| IHC predicted cell location | Predicted cell location: Cytoplasm |
| IHC positive control | Positive control: Human thyroid cancer |
| IHC Recommed dilution | Recommended dilution: 50-200 |
Storage
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
WB PIC Description
P103377-WB-1-P
IHC PIC Description
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue or COX7A2L antigen-treated (Neutralization experiment) using P103377(COX7A2L Antibody) at dilution 1/65
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