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Full name | COL25A1 rabbit polyclonal antibody |
Alternative names | 50 μl/100 μl |
Reactivity | rabbit polyclonal |
Applications | WB, IHC |
Host | Rabbit |
Clone type | rabbit polyclonal |
Target Background | This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. |
Swissprot No | Q9BXS0 |
Gene Accession | NP_942014 |
WB Predicted band size | |
WB Positive control | P104147-WB-1-P |
WB Recommended dilution | 65 kDa |
IHC predicted cell location | Predicted cell location: Cytoplasm |
IHC positive control | Positive control: Human liver cancer |
IHC Recommed dilution | Recommended dilution: 30-150 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
P104147-WB-1-P
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue or COL25A1 antigen-treated (Neutralization experiment) using P104147(COL25A1 Antibody) at dilution 1/25
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