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Sku: P100163-50 μl

Specification

Full name CDK6 rabbit polyclonal antibody
Alternative names 50 μl/100 μl
Reactivity rabbit polyclonal
Applications WB, IHC
Host Rabbit
Clone type rabbit polyclonal
Target Background The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly.
Swissprot No Q00534
Gene Accession BC052264
WB Predicted band size Immunohistochemical analysis of paraffin-embedded Human colorectal cancer tissue or CDK6 antigen-treated (Neutralization experiment) using P100163(CDK6 Antibody) at dilution 1/55
WB Positive control P100163-WB-1-P
WB Recommended dilution 37 kDa
IHC predicted cell location Predicted cell location: Cytoplasm
IHC positive control Positive control: Human liver cancer
IHC Recommed dilution Recommended dilution: 50-200

Storage

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

WB PIC Description

P100163-WB-1-P

IHC PIC Description

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue or CDK6 antigen-treated (Neutralization experiment) using P100163(CDK6 Antibody) at dilution 1/55

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