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Full name | CASP10 rabbit polyclonal antibody |
Alternative names | 50 μl/100 μl |
Reactivity | rabbit polyclonal |
Applications | WB, IHC |
Host | Rabbit |
Clone type | rabbit polyclonal |
Target Background | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
Swissprot No | Q92851 |
Gene Accession | NP_116759 |
WB Predicted band size | Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue or CASP10 antigen-treated (Neutralization experiment) using P114441(CASP10 Antibody) at dilution 1/25 |
WB Positive control | P114441-WB-1-P |
WB Recommended dilution | 59 kDa |
IHC predicted cell location | Predicted cell location: Cytoplasm |
IHC positive control | Positive control: Human breast cancer |
IHC Recommed dilution | Recommended dilution: 25-50 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
P114441-WB-1-P
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue or CASP10 antigen-treated (Neutralization experiment) using P114441(CASP10 Antibody) at dilution 1/25
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